Demonstration of an inoculum effect on the estimation of the minimal inhibitory concentration of LY 146032
Flandrois, J.P.; Carret, G.; Pichat, C.; Peyret, M.
Pathologie-Biologie 36(5): 377-380
1988
ISSN/ISBN: 0369-8114 PMID: 2841637 Document Number: 321278
This work has been performed to study the inoculum effect on the in vitro activity of LY 146032, a new lipopeptide antibiotic. A statistical analysis (X2 and t test) of the data concerning the MIC of different bacterial groups has been carried out to appreciate the phenomenon. The activity of vancomycin has been compared. A major inoculum effect has been detected for LY 146032. It must be taken into account to evaluate the activity of this new antibiotic.
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