What does the minimal inhibitory concentration of an antibiotic hide from the clinician? Experimental examples
Gerber, A.U.; Feller-Segessenmann, C.; Craig, W.A.
Schweizerische Medizinische Wochenschrift 113(2): 34-37
1983
ISSN/ISBN: 0036-7672 PMID: 6402813 Document Number: 204838
Examples are presented to demonstrate that in-vitro determinations of the minimal inhibitory concentration of antibiotics do not take into account factors of presumable in-vivo significance: pH and divalent cations in the medium, protein binding of antimicrobials, and the bacterial inoculum effect.
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