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The correlation between the clinical effectiveness and ratio of blood concentration to minimum inhibitory concentration of sulfamethoxazole against Escherichia coli isolates. the determination of a parameter in a dosage equation by the pharmacokinetics

Otaya, H.; Kuraoka, Y.

International Journal of Clinical Pharmacology and Biopharmacy 12(4): 395-402

1975

ISSN/ISBN: 0340-0026
PMID: 1107237
Document Number: 85505
The correlation between the clinical effectiveness and ratio of blood concentration to minimum inhibitory concentration of sulfamethoxazole against Escherichia coli isolated from clinical specimens were studied. This value is one of important parameters in a dosage equation by the pharmacokinetics, it showing sigma in an equation, were determined by clinical trial for acute simple cystitis of women. The sigma values were justified as 4 or more.

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