Correlation between the thickness of air-blood barrier of the lung and main indices of respiration during changes in oxygen concentration
Tavolzhanova, T.I.; Rozova, K.V.; Dubova, M.H.; Petrenko, O.V.
Fiziolohichnyi Zhurnal 50(3): 24-29
2004
ISSN/ISBN: 2522-9028 PMID: 15320426 Document Number: 579547
In experiments on adult white laboratory rats the correlation among external respiration, gas exchange and blood O2 transport under breathing by air and gas mixtures with 40%, 14.5%, 11% and 7% O2 in N2 was investigated. It was demonstrated the narrow structural-functional interrelation in oxygen transport system. The thickness of air-blood barrier (ABB) correlates not only with the external respiration and diffusion capacity of lung, but with parameters, which are not directly connected with the state of lung tissue, such as oxygen content in venous blood, VaO2/VO2 and even with circulation volume. The existence of narrow correlation of ABB thickness and the most of investigated parameters permits to prognosticate the availability of structural disturbances in the presence of external respiration, gas exchange and blood O2 transport changes.