Enhancement of antitoxic immunity in newborn infants by peroral administration of donor antistaphylococcal immunoglobulin
Manolova, E.P.; Tret'iakevich, Z.N.; Khripko, S.V.; Mechetnaia, I.N.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 1: 49-51
1988
ISSN/ISBN: 0372-9311 PMID: 3364073 Document Number: 318406
The possibility of enhancing specific immunity by the oral administration of homologous antistaphylococcal immunoglobulin in a dose of 50 I. U./kg b. w. before the first feeding was shown in 75 newborn infants with a high risk of staphylococcal infection. 24 hours after the first administration of Ig the titer of staphylococcal anti-alpha toxin in the blood rose from 0.68 +/- 0.05 I. U./ml to 2.9 +/- 0.14 I. U/ml, on day 7 this titer persisted at the level of 2.86 +/- 0.12 I. U./ml, and 3 months later the titer was 1.5 +/- 0.05 I. U./ml. No side effects were observed. In the reference group (50 infants) antitoxic titers remained low. No suppurative-septic diseases were observed in the test group within 3 months, while in the controls, focal forms of staphylococcal infection (12 cases) and sepsis (1 case) were registered.