Humoral factors of local and systemic immunity in the multiple peroral administration of a corpuscular pertussis vaccine
Zakharova, N.S.; Vlasov, G.S.; Kuz'min, S.N.; Pershin, B.B.; Salov, V.F.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 11: 64-69
1985
ISSN/ISBN: 0372-9311 PMID: 2868593 Document Number: 257838
Multiple oral immunization with pertussis corpuscular vaccine was shown to lead to the considerable stimulation of local and systemic humoral immunity. The data on the titers of specific and normal secretory antibodies, on the levels of IgA in washings from the oral cavity, the small intestine and the lungs, on the titers of agglutinins and hemagglutinins in the blood serum, as well as on the morpho-functional transformation of the mucous membrane and the associated lymphoid tissue in the digestive tract, are presented in their dynamics. Specific pertussis antibodies in high titers were detected in both intestinal and pulmonary washings. The multiple administration of the vaccine did not produce pathological changes in internal organs.