The intensity and dynamics of the development of immunity in the administration of experimental corpuscular ozena vaccines
Molochko, V.A.; Krasil'nikov, A.P.; Krylov, I.A.; Lastochkina, T.M.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 5: 49-52
1988
ISSN/ISBN: 0372-9311 PMID: 3414235 Document Number: 315190
Experiments on the active protection of mice from ozenous infection in its two forms, generalized (acute sepsis) and local (plantar infiltration), have demonstrated that immunity, induced by experimental heat-killed ozena vaccine (Klebsiella ozaenae strain 2211, antigens 02B:K4) introduced in a single injection, is characterized by sufficiently high intensity (the degree of protection increases up to 10,000-fold) and duration (at least 30 days). In both forms the development of immunity is characterized by a rapid rise of its intensity to the maximum level (achieved by the end of week 1), subsequent decrease by weeks 3-4 and disappearance by days 50-60 after immunization. Immunity becomes more intense with the increase of the number of injections if these injections are separated by sufficient intervals (up to 14 days). The optimum schedule used in the study of postvaccinal immunity to experimental generalized and local ozenous infection consists of the subcutaneous injection of K. ozaenae strain 2211 in a dose of 250-500 million microbial bodies per mouse with the subsequent challenge with the virulent strain on week 2 from the date of immunization.