Effect of glycine-steatamide or glutamic acid palmitamide on oral dyskinesia, obtained by a single administration of haloperidol combined with GABA-linoleamide in rats
Vamvakidès, A.
Annales Pharmaceutiques Francaises 46(4): 261-266
1988
ISSN/ISBN: 0003-4509 PMID: 3074729 Document Number: 318296
The oral dyskinesias (OD), obtained on Wistar female rats by the administration of haloperidol (0,6 mg/kg, i.p.) and GABA-linoleamide (10 mg/kg, i.p.) [Hal 0,6 .+-. GL 10], were antagonized by the addition of glycine-steatamide (10 mg/kg, i.p.) [Hal 0,6 .+-. GL 10+ SG 10], or glutamic acid palmitamide (150 mg/kg, i.p.) [Hal 0,6 + GL 10 + PGt 150]. The addition of the SG at 150 mg/kg (i.p.) [Hal 0,6 + GL 10 + SG 150], or of the PGt at 10 mg/kg (i.p.) [Hal 0,6 + GL 10 + PGt 10], was without effect on these OD. These results could be the reflection of the impact of those two derivatives (SG, PGt), on the glycinergic or glutamatergic brain receptors of the rate.