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Effect of berberine on pharmacokinetics of digoxin after oral administration to rats

Ju, Y.; Qiu, W.; Jiang, X.; Liu, C.

Zhongguo Zhong Yao Za Zhi 36(7): 918-921

2011

ISSN/ISBN: 1001-5302
PMID: 21761735
Document Number: 653705
To study the effects of berberine (BBR) on the pharmacokinetics of digoxin (DIG) in rats. Rats were randomly assigned into DIG, low dose-BBR, middle dose-BBR and high dose-BBR group. After singe or a 2-week ig pretreatment with BBR, serum DIG concentration was determined by radioimmunoassay. Pharmacokinetic calculations were performed on each individual set of data using 3P97 practical pharmacokinetic software. No significant difference was found between the control and 10 mg x kg(-1) BBR combined group. After pretreatment with BBR (30, 100 mg x kg(-1)), the pharmacokinetic parameters of ig DIG were significantly altered. The AUC(0-t) of DIG with BBR increased by 33% and 70% (single), 27% and 75% (2-week), respectively. BBR increases bioavailability of DIG, which may be related to its inhibition effect on intestinal P-gp.

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