Changes in the liver following a single administration of 11-H-eicosafluoroundecanoic acid in rats
Schmidt, P.; Burck, D.; Bürger, A.
Acta Biologica et Medica Germanica 37(8): 1305-1309
1978
ISSN/ISBN: 0001-5318 PMID: 749467 Document Number: 133632
A single oral administration of 27 mg 11-H-eicosafluorundecanoic acid/kg of body weight (according to 1/20 of the oral LD50; 0.049 mM) resulted in a long lasting hepatomegaly in male rats. This was accompanied by a decrease of the triglyceride and total lipid levels in blood serum, a temporary increase of the total lipids in the liver, and an increase of the hexobarbital sleeping time, the latter being normalized before the liver/body weight ratio reached the control level. The bromothalein elimination and the S-alanine amino transferase and S-alkaline phosphatase activities were not affected.