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Sulfadimezine and sulfamomomethoxine distribution in the body of white rats in single and repeated administration in combination with UV irradiation

Matveeva, S.A.

Farmakologiia i Toksikologiia 42(3): 288-291

1979

ISSN/ISBN: 0014-8318
PMID: 446714
Document Number: 141890
Experiments on white rats showed that single administration of sulfadimesin or sulfamonomethoxin combined with UV irradiation delays absorption, increases acetylation rate and diminishes excretion of the drugs with urine. During prolonged investigations it was established that repeated combined administration of sulfadimesin and UV irradiation produces a drop in the drug level in the blood and organs, increases acetylation rate and total acetylation activity in the body. Repeated combined administration of sulfamonomethoxin and UV irradiation produces a wave-like changes in the dynamics of the drug accumulation in the body and organs. Acetylation rate and total acetylation activity of the body rise as was shown in the course of prolonged investigations.

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