Increased apoptosis in the adult rat liver after a single dose of adriamycin administration
Pedrycz, A.; Wieczorski, M.; Czerny, K.
Annales Universitatis Mariae Curie-Sklodowska. Sectio D Medicina 59(2): 313-318
2004
ISSN/ISBN: 0066-2240 PMID: 16146099 Document Number: 567498
The purpose of this study was the evaluation of hepatocytes in the adult rat's liver after adriamycin administration in a single dose. The presented above morphological changes, on tissue, cell and ultrastructural level are the evidence of persistent and irreversible damage of liver tissue via adriamycin. Cells damaged in that way waste away. In the present study cell death touched mainly single cells and necrosis was not observed. It is the evidence of apoptosis--the natural death of cells.