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Effect of acute hypoxia on the renin and erythropoietin activities of the blood serum in rats

Kalacheva, N.M.; Zaĭchik, A.M.; Pavlov, A.D.; Morshchakova, E.F.

Biulleten' Eksperimental'noi Biologii i Meditsiny 105(3): 281-283

1988

ISSN/ISBN: 0365-9615
PMID: 3280049
Document Number: 318260
A comparative study of renin and erythropoietin content in the blood serum of rats with "endocrine" kidneys and changes in their activity following the action of specific erythropoietic stimulus (4-hour hypoxia) has been conducted. The presence of "endocrine" kidneys increased renin and erythropoietin activity in such animals. Acute hypoxia produced further increase in erythropoietin titre in the blood serum, with renin remaining at the same level. Possible differences in the mechanisms of renin and erythropoietin biogenesis in the kidneys are considered.

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