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Effect of vitamin A on hepatic microsomal drug metabolising enzymes activity in rats exposed to acute hypoxia

Grover, S.K.; Srivastava, K.K.; Singh, V.S.; Misra, U.K.

International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 55(4): 391-393

1985

ISSN/ISBN: 0300-9831
PMID: 4086207
Document Number: 263863
The hepatic drug metabolising enzymes activity has been studied in rats exposed to acute hypoxia alone or along with supplementation of single dose of 10000 I.U. Vitamin A. Hypoxic stress reduces the activities of cytochrome P-450, cytochrome c-reductase and aniline hydroxylase. Administration of single dose of 10000 I.U. of Vitamin A to the rats 12 h before hypoxia reverses the effect of hypoxia on these enzymes. Thus Vitamin A seems to play a protective role in rats exposed to hypoxia on the activity of MFO system.

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