Influence of the plasticiser di-2-ethylhexyl-phthalate on drug metabolising enzymes in the liver of uraemic rats
Leber, H.W.; Uviss, T.; Prenter, A.
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association 16: 232-237
1979
ISSN/ISBN: 0071-2736 PMID: 548985 Document Number: 151111
After bilateral or subtotal nephrectomy male rats were given intraperitoneal injections of the plasticiser di-2-ethylhexylphthalate (DEHP) at differing time intervals in doses that do not affect the liver of normal rats. 200mg DEHP/100g body weight had no influence on the parameters measured. After administering 7 x 200mg/100g body weight for 14 days, liver weight and in vitro activity of the mixed function oxidation system increased significantly. In addition, the hexobarbital sleeping time decreased, indicating a stimulation of the activity of drug metabolising enzymes in vivo. Similar results were obtained after the administration of 56 x 50mg DEHP/100g body weight for 19 weeks. It is concluded that uraemic rats are more susceptible to inducing effects, but that the DEHP toxicity is of little importance.