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Hypocholesterolemic effect of hepatic microsomal enzymes in rats

Salganik, R.I.; Manankova, N.M.; Semenova, L.A.

Voprosy Meditsinskoi Khimii 23(4): 468-473

1977

ISSN/ISBN: 0042-8809
PMID: 919369
Document Number: 114619
An inductor of microsomal enzymes 9-acetate-16alpha-isothiocyanogen pregnenolone (ATCP), administered into rats within 5 days after termination of feeding with an atherogenic diet, caused normalization of cholesterol content in blood, of beta-lipoproteins spectrum as well as the structure of liver cells. At the same time, in animals, which were not treated with ATCP, high level of cholesterol was maintained in blood serum; reducing smooth endoplasmic reticulum and a decrease in content of glycogen in hepatocytes were also observed. Enzymatic oxidation of cholesterol into 7alpha-hydroxycholesterol, distinctly stimulated by ATCP, appears to be the cause of increased elimination of cholesterol from the organism. ATCP might be used as a drug decreasing the content of cholesterol in blood of patients with hypercholesterolemia.

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