Protective activity of preparations of blood plasma from donors with a high titer of natural antibodies to Re-glycolipid of gram-negative bacteria
Rudik, A.A.; Kropacheva, E.I.; Apollonin, A.V.; Sevast'ianova, E.K.; Likhoded, V.G.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 7: 60-63
1988
ISSN/ISBN: 0372-9311 PMID: 3188736 Document Number: 317350
The screening of the preparations of blood plasma obtained from 1,608 donors made it possible to establish the presence of high titers of natural antibodies to Re-glycolipid in 3% of the donors. Donor plasma containing antibodies to Re-glycolipid in a titer of 1:128 ensured a high level of protection for mice in experimental fecal peritonitis. The treatment of 10 patients having commonly occurring forms of peritonitis, caused by Gram-negative bacteria, with the use of such plasma yielded a positive clinical effect. The presence of correlation between the titers of antibodies to Re-glycolipid in blood plasma preparations and the content of high-density lipoproteids, expressed in per cent, was noted.