Influence of drugs on the TXA2/PGI2 balance and on the atherogenic index in myocardial ischemia in dogs
Beitz, A.; Taube, C.; Beitz, J.; Goos, H.; Graff, J.; Nohring, J.; Lindenau, K.F.; Mest, H.J.
Biomedica Biochimica Acta 47(10-11): S149-S152
1988
ISSN/ISBN: 0232-766X PMID: 2470353 Document Number: 316109
The effect of drugs on eicosanoid production and on the development of atherogenic index was investigated in canine myocardial ischemia. Iloprost, verapamil, the trapidil derivative AR 12463 or 0.9% NaCl solution were administered 60 min after coronary artery ligation in anaesthetized dogs. Both iloprost and AR 12463 reduced the thromboxane A2/prostacyclin (TXA2/PGI2) ratio in coronary sinus plasma in comparison to controls. The atherogenic index was significantly decreased in the iloprost as well as in the AR 12463-treated group in comparison to the control group. Verapamil had no influence on the investigated parameters.