Adhesive molecules as drugs and objects of pharmacological effect in myocardial ischemia and reperfusion
Uteshev, D.B.; Uteshev, B.S.
Eksperimental'naia i Klinicheskaia Farmakologiia 60(3): 83-88
1997
ISSN/ISBN: 0869-2092 PMID: 9324410 Document Number: 474915
The modern advancements in the study of the mechanisms of reperfusion damage in myocardial infarction are analysed. Emphasis is placed on the leukocyte-endothelial interactions and the role of various adhesive molecules and cytokines. The effect of various biotechnological agents and drugs, products of chemical synthesis, on some links of the reperfusion syndrome are discussed. A classification of substances possessing a protective effect in ischemia/reperfusion is proposed.