Effects of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin on myocardial dysfunction after a brief ischemia in anesthetized dogs
Chang, T.H.; Adachi, H.; Okuyama, T.; Zhang, K.Y.
Zhongguo Yao Li Xue Bao 15(5): 388-391
1994
ISSN/ISBN: 0253-9756 PMID: 7717058 Document Number: 426852
The effect of a 30-min infusion of 3'-angeloyloxy-4-acetoxy-3', 4'-dihydroseselin (Pd-Ia), a coumarin isolated from Peucedanum praeruptorum Dunn 0.15 mg cntdot kg-1 cntdot min-1 on regional myocardial dysfunction was examined in 16 anesthetized open-chest dogs subjected to a 15-min occlusion of the left anterior descending coronary artery followed by a 3-h reperfusion. Segment lengths of left ventricular wall were measured with an ultrasonic micrometer. The control caused a decrease in the % of segment shortening (SS %) throughout the reperfusion period (n=8), while Pd-Ia ameliorated segment function immediately after reperfusion and restored the SS % to 41 +- 51% of the baseline value (n = 8, P lt 0.05 vs control) 5 min after reperfusion without any significant changes in cardiohemodynamics. The improvement of myocardial function induced by Pd-Ia was maintained at least 3 h after reperfusion. These findings revealed that Pd-Ia had a cardioprotective action in stunned myocardium.