The cardiovascular effects of peruvoside and neriifolin in anesthetized dogs
Zeng, G.Y.
Zhonghua Xin Xue Guan Bing Za Zhi 11(4): 305-307
1983
ISSN/ISBN: 0253-3758 PMID: 6673953 Document Number: 220019
The cardiovascular effects of peruvoside on anesthetized open chest dogs and the actions of neriifolin on dogs with or without heart failure were studied. In normal dogs i.v. administration of 50 .mu.g/kg peruvoside (n = 6) decreased heart rate (HR) and increased aortic systolic or diastolic pressure, left ventricular systolic pressure (LVSP), the rate of change of intraventicular pressure (LV dp/dt max), cardiac index (CI), stroke volume index (SVI), left ventricular work index (LVWI) and myocardial oxygen consumption (MVO2). After i.v. injection of 50 .mu.g/kg neriifolin in normal dogs (n = 7), all the above indices except HR and SVI were also markedly augmented. Both of the glycosides showed powerful positive inotropic effect in normal dogs. After neriifolin adminstration (n = 4) the cardiac performance of failing heart induced by sodium pentobarbital was significantly improved. However, the MVO2 was not significantly changed. The positive inotropic effect of neriifolin on failing heart was more obvious than in normal heart. In the normal anesthetized dogs, peruvoside enhanced the coronary, femoral and total systemic vascular resistance. Neriifolin increased the coronary blood flow without major changes in cerebral or femoral blood flow; the vascular resistance of the 3 arteries was not significantly changed either. However, the total systemic vascular resistance increased. Neriifolin appeared to be slightly less vasoconstrictive than peruvoside. Neriifolin and peruvoside are powerful cardiac glycosides with relatively mild side effects and are absorbed rapidly from the gastrointestinal tract. The two glycosides may be used in heart failure.