Hemodynamic effects of total alkaloids of Uncaria macrophylla in anesthetized dogs
Liu, G.X.; Huang, X.N.; Peng, Y.
Zhongguo Yao Li Xue Bao 4(2): 114-116
1983
ISSN/ISBN: 0253-9756 PMID: 6225297 Document Number: 204678
In 12 anesthetized dogs, cardiac output was determined by an impedance cardiograph. I.v. infusion of the total alkaloids 20 mg/kg produced a moderate hypotension accompanied by a marked bradycardia. The cardiac output increased temporarily and then decreased slightly, whereas the stroke volume consistently elevated. The total peripheral resistance diminished during initial hypotension. The possible cause of hypotension may be a reduction of both cardiac output and peripheral resistance.