Effects of Gosha-Jinki-Gan on the function of the urinary bladder in anesthetized dogs
Suzuki, T.; Kurokawa, K.; Suzuki, K.; Higashi, H.; Ohma, C.; Imai, K.; Yamanaka, H.
Hinyokika Kiyo. Acta Urologica Japonica 42(12): 951-955
1996
ISSN/ISBN: 0018-1994 PMID: 9013230 Document Number: 456612
Gosha-Jinki-Gan is clinically used for the treatment of pollakiuria in patients with benign prostatic hyperplasia. The effect of Gosha-Jinki-Gan on the function of the urinary bladder in anesthetized dogs was examined. Gosha-Jinki-Gan (100 mg/kg) inhibited the rhythmic bladder contractions (RBC). However, the frequency of RBC increased resembling the effect of atropine (0.1 mg/body), and the amplitude decreased. On the cystometrogram, Gosha-Jinki-Gan caused an increase in maximum vesical volume (not significant). These findings indicated that Gosha-Jinki-Gan is a useful drug for the treatment of pollakiuria.