Experimental ocular onchocerciasis in cynomolgus monkeys. III. Roles of IgG and IgE antibody and autoantibody and cell-mediated immunity in the chorioretinitis elicited by intravitreal Onchocerca lienalis microfilariae
Donnelly, J.J.; Semba, R.D.; Xi, M.S.; Young, E.; Taylor, H.R.; Rockey, J.H.
Tropical Medicine and Parasitology Official Organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft für Technische Zusammenarbeit 39(2): 111-116
1988
ISSN/ISBN: 0177-2392 PMID: 3175465 Document Number: 315703
Intravitreal injection of 10-500 O. lienalis microfilariae (mf) of Macaca fascicularis induces posterior segment lesions which resemble those occurring in human onchocerciasis in some respects. In order to determine the potential roles of antibody and cell-mediated immune responses in the formation of these lesions, anti-Onchocerca and anti-retinal IgG and IgE antibody and peripheral lymphocyte blastogenic responses were followed in 8 monkeys, for one week to 5 months after intravitreal injection of mf. Significant ocular inflammation occurred well before any antibody or peripheral lymphocyte blastogenic responses could be detected. Direct effects of mf (such as activation of complement via the alternative pathway) may play important roles in the pathogenesis of the posterior segment lesions.