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Differential regulation of effector responses of cell mediated immunity in experimental salmonellosis

George, A.; Rath, S.; Kamat, R.S.

Clinical and Experimental Immunology 63(2): 327-333

1986

ISSN/ISBN: 0009-9104
PMID: 2938854
Document Number: 270292
Delayed type hypersensitivity (DTH) and protective cell mediated immunity showed different profiles with respect to time following intraperitoneal immunization with live Salmonella enteritidis. Whereas the DTH response decreased with time the Protection Index increased. The decline in DTH response was found to be associated with suppressor cells generated by intraperitoneal immunization and could be prevented by cyclophosphamide treatment prior to immunization. It was concluded that the two effector responses of cell mediated immunity were under differential regulation.

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