Effects of ketoprofen and other drugs on release of prostaglandins from uterus of rabbits in perinatal period
Ueno, K.; Masumura, H.; Kawamoto, H.; Kitagawa, H.
Research Communications in Chemical Pathology and Pharmacology 59(1): 141-144
1988
ISSN/ISBN: 0034-5164 PMID: 3162594 Document Number: 308440
The effects of oral administration of ketoprofen, naproxen, flurbiprofen (1.0 mg/kg), indomethacin (1.0 and 3.0 mg/kg), and acetylsalicyclic acid (100 mg/kg) on release of prostaglandin F2.alpha. (PGF2.alpha.) and prostaglandin E (PGE) from isolated pregnant rabbit uterus were studied comparatively. Ketoprofen, indomethacin, flurbiprofen, naproxen and acetylsalicyclic acid reduced the release of PGF2.alpha. and PGE from the isolated rabbit uterus. The inhibitory effect was most profound with flurbiprofen, followed, in order, by naproxen, ketoprofen, indomethacin and acetylsalicylic acid. A comparative study with intramuscular ketoprofen (0.1, 1.0 and 3.0 mg/kg) was also carried out. The inhibitory effect of ketoprofen on uterine PGF2.alpha. and PGE release with intramuscular route was about 10 times more profound than that with oral route.