Influence of prostaglandins upon adenosine release and of adenosine upon prostaglandin release in the isolated rabbit heart
Zehl, U.; Ritter, C.; Förster, W.
Acta Biologica et Medica Germanica 35(11): K77-K82
1976
ISSN/ISBN: 0001-5318 PMID: 1022127 Document Number: 97314
Prostaglandin (PG) E1 with its high effect of coronary dilation causes a distinct increase in the adenosine release from the isolated rabbit heart (Langendorff technique). Compared to this, an equal dose of PGF2alpha increases the release of adenosine only to a small extent. Conversely, application of adenosine results in a considerable release of PG-like substances from the rabbit heart in vitro. The present investigations support the hypothesis that, apart from adenosine, PG's too, are involved in coronary regulation as modulators.