Effects of anti-inflammatory drugs on platelet aggregation in rabbits
Takano, S.; Aikawa, T.; Oishi, T.; Goto, M.; Tamura, O.; Suzuki, T.
Research Communications in Chemical Pathology and Pharmacology 24(3): 501-514
1979
ISSN/ISBN: 0034-5164 PMID: 451335 Document Number: 141478
Effects of non-steroidal anti-inflammatory drugs (aspirin, indomethacin, flufenamic acid, tiaramide and HG-70 [N-cyclohexyl-N'-(2-methoxy-5-chlorophenyl) benzamidine]) on rabbit platelet aggregation were studied using Evans aggoregometer and a modified form of Chandler's loop method. Tiaramide in 10-4 and 10-5 M inhibited effectively the aggregation caused by ADP in the optical density method and accelerated the restoration of the time course of disaggregation in the loop method. The other 4 drugs were ineffective. In collagen-induced aggregation all 5 drugs inhibited the aggregation. Among them tiaramide was most potent. Only tiaramide prolonged the time taken to induce snow storm and aggregates in the loop method.