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Anti-platelet-aggregation drugs and atherosclerosis

Mauro, R.; Calatola, P.; Di Donato, F.; Frey, L.; Lettieri, A.

Minerva Medica 69(33): 2285-2288

1978

ISSN/ISBN: 0026-4806
PMID: 683581
Document Number: 136532
The relationship between hyperlipidaemia and thrombophilic state in atherosclerosis was appraised by evaluation of platelet aggregation according to Breddin in 20 patients with clinically established atherosclerosis, 10 normal controls, and 22 subjects taken from the average population of a medical department aged 12-58 yr with no history of atherosclerosis. Normal screening for the disease was carried out in all patients. Drugs inhibiting platelet-aggregation were given to all subjects in Breddin's 3rd or 4th stage. A relationship was noted between Breddin stage and the seriousness of atherosclerosis, while the former was a pointer to thrombophilic states. The drugs administered were able to reverse the aggregation stage.

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