Platelet aggregation: inhibition of secondary aggregation by phenol
Coan, M.L.; Case, K.R.; Bosmann, H.B.
Research Communications in Chemical Pathology and Pharmacology 36(2): 241-249
1982
ISSN/ISBN: 0034-5164 PMID: 6808618 Document Number: 191836
Abnormal platelet function in patients with chronic renal failure is associated with elevated levels of phenol and phenolic acids in serum. In vitro studies show inhibition of secondary aggregation by phenol, suggesting that phenol acts at the platelet release reaction. When platelet rich plasma was incubated with phenol, inhibition was found to decrease with increasing preincubation time at 37.degree. C, but not at 0.degree. C. The inhibitory effect of phenol in vitro was overcome by the addition of arachidonic acid. These findings demonstrate inhibition of secondary aggregation by phenol. The site of the inhibitory action of phenol was at the initiation of the secondary wave of platelet aggregation.