Phenobarbital--an inducer of bilignost excretion with the bile in rats
Shimanovskiĭ, N.L.; Bolotva, E.N.; Volkov, A.F.; Manuĭlov, K.K.
Farmakologiia i Toksikologiia 51(2): 94-97
1988
ISSN/ISBN: 0014-8318 PMID: 3378617 Document Number: 305687
It was found that a preliminary administration of phenobarbital to rats caused an increase of the rate of 125I-bilignost excretion in the bile by 46.6% but reduced its half-life in the blood by 48.3% and its excretion in the urine by 46.4%. Phenobarbital decreased the rate of 125I-bilignost absorption by the liver slices and increased the rate of release from them.
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