Ceftriaxone in malignant occlusive jaundice. Studies of serum and bile concentration in disordered bile excretion
Maikowski, C.; Rösch, W.; Sörgel, F.
Fortschritte der Medizin 111(32): 513-516
1993
ISSN/ISBN: 0015-8178 PMID: 8294078 Document Number: 420120
In 12 patients with inoperable malignant obstructive jaundice, percutaneous transhepatic biliary drainage was performed to decompensate the bile ducts. For a period of 7 days, the patients received a single daily i.v. dose of 1 g CFTX, and the serum and bile concentrations were measured at defined intervals. The dose sufficed to kill about 85% of the expected organisms. Although an accumulation of the substance as documented under conditions of normal bile flow was not demonstrable under cholestatic conditions, effective levels were nevertheless found in the bile and showed a tendency to increase with increasing bile flow.