Drugs derived from thiazole and imidazole or with nitrogen-carbon-sulphur or tertiary amino groups. Prediction of secondary antithyroid activity by UV/visible spectroscopy
Jambut-Absil, A.C.; Buxeraud, J.; Claude, J.; Raby, C.
Arzneimittel-Forschung 37(7): 772-777
1987
ISSN/ISBN: 0004-4172 PMID: 2445359 Document Number: 302599
The chemical structure of various drugs suggests their potential interference with thyroid metabolism by complexing molecular iodine in the thyroid gland. Spectroscopic analysis shows that such compounds form charge-transfer complexes with iodine in a 1:1 stoichiometry. The values of formation constant Kc indicate strong donor-acceptor interactions. Biochemical and histological studies carried out on the rat demonstrated that a correlation exists between the Kc values and the antithyroid activity. A mechanism of action of these molecules on thyroid function is proposed. The potential antithyroid activity of such compounds can therefore be predicted from the Kc values.