Impact of mycobacteria on nonspecific protective mechanisms associated with exchange of organic sulphur and nitrogen
Pavlov, V.A.
Problemy Tuberkuleza 1997(3): 48-51
1997
ISSN/ISBN: 0032-9533 PMID: 9265175 Document Number: 472594
Guinea-pig experiments indicated that Mycobacteria tuberculosis (MBT) were actively involved in detoxification of the xenobiotics polycyclic aromatic hydrocarbons (PAH) and substantially altered the nonspecific protective mechanisms associated with activation of the body's antioxidative resources. MBT in the lung and liver tissues of animals long preexposed to PAH elevated the concentrations of sulphur-containing amino acids and glutathione with consumption of abundant nitrogen-rich adaptogenic antioxidants (arginine, urea) accumulated under the action of PAH. At the same time there is a upward trend for the body's antioxidative potentials both in a group infection with MBT and in group receiving PAH. Supplementing sodium glutamate potentiated the revealed adaptive rearrangements.