Some problems of the therapy of chronic glomerulonephritis
Riabov, S.I.; Stavskaia, V.V.
Terapevticheskii Arkhiv 59(11): 66-71
1987
ISSN/ISBN: 0040-3660 PMID: 3441869 Document Number: 301725
A study of the results of therapy of exacerbations of chronic glomerulonephritides in 416 patients during the entire course of the disease has shown their dependence on the clinical and, to a lesser degree, on morphological peculiarities of disease. With the same anatomy of the process, the efficacy of glucocorticoids, cytostatics and their combinations with anticoagulants and antiaggregants was less in the presence of the nephrotic syndrome and got lower twice or thrice in patients with a tendency to continuous recurrence. The results of the use of all types of therapy in groups of patients identical by their clinical characteristics were worse in membranous glomerulonephritis and did not differ significantly in mesangioproliferative and membranoproliferative glomerulonephritides. The treatment of the latter was less effective than that of mesangioproliferative glomerulonephritis because of higher frequency of an active course and development of the nephrotic syndrome.