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Characteristics of carbohydrate metabolic disorders and of the secretion of insulin, glucagon and somatotropin in patients with chronic glomerulonephritis and chronic kidney failure

Trusov, V.V.; Kazakova, I.A.; Nasachev, A.A.

Terapevticheskii Arkhiv 58(8): 13-18

1986

ISSN/ISBN: 0040-3660
PMID: 3532406
Document Number: 269563
A course of chronic glomerulonephritis is accompanied by carbohydrate metabolic derangement (a decrease in glucose tolerance), change in insulin secretion and the development of relative insulin insufficiency. The revealed changes develop up to the appearance of the clinical signs of chronic renal failure and progress with its development. A decrease in renal function and the development of chronic renal failure is accompanied by the accumulation of insulin hormonal antagonists: somatotropin, glucagon and prolactin. Treatment with chronic hemodialysis does not completely eliminate carbohydrate metabolic derangements, nor does it correct growth hormone, glucagon and prolactin secretion.

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