Relation between blood somatostatin concentration and somatotropin, insulin and glucagon secretion in endocrine diseases
Slavnov, V.N.; Epshteĭn, E.V.; Efimov, A.S.; Luchitskiĭ, E.V.
Problemy Endokrinologii 27(2): 3-6
1981
ISSN/ISBN: 0375-9660 PMID: 6112741 Document Number: 171540
Somatostatin content in the blood of healthy persons, of patients with cerebral nanism, diabetes mellitus, Icenko-Cushing's disease, and obesity, was studied by radioimmuno--assay. Comparative analysis of somatostatin, somatotropin, glucagon and immunoreactive insulin content in the blood of patients with different endocrine disturbances was carried out. Significant elevation of somatostatin level was revealed in cerebral nanism. An increase in the blood somatostatin concentration of patients with diabetes mellitus, Icenko-Cushing's disease and obesity was accompanied by a fall in somatotropin and glucagon secretion and a rise in the blood insulin level.