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Glucagon-secreting pancreatic islet cell carcinoma, containing insulin and somatostatin, with hypoglycemic attack

Yano, T.; Yamamoto, N.; Fujimori, K.; Inamori, S.; Hayashi, H.; Mizumoto, R.

American Journal of Gastroenterology 77(6): 387-391

1982

ISSN/ISBN: 0002-9270
PMID: 6124121
Document Number: 195923
A patient with glucagonoma syndrome and hypoglycemic attack is presented. Total pancreatectomy was performed with splenectomy and excision of the metastatic nodule in the liver. Diagnosis of glucagon-secreting A cell carcinoma of the pancreas was confirmed by hormone assays and morphological studies with light and electron microscopy. Glucagon, insulin, and somatostatin were demonstrated immunohistochemically in the tumor tissue. Multihormonal features of the endocrine pancreatic tumors are discussed.

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Ferrara, J.J.; Fucci, J.C.; Benson, J.B. 1985: Metastatic pancreatic islet cell carcinoma causing manifestations of glucagon and gastrin hypersecretion Connecticut Medicine 49(12): 777-780
Drost, H.; Berger, M.; Berchtold, P.; Wiegelmann, W.; Zimmermann, H.; Gries, F.A. 1976: Behavior of plasma glucagon in experimental fasting and somatostatin test in islet cell tumors Die Medizinische Welt 27(28): 1381-1383
Leigh, C.M.; Edwin, N. 1997: Immunocytochemical identification of cells containing insulin, glucagon, somatostatin, and pancreatic polypeptide in islets of Langerhans of the wombat pancreas with electron microscopy European Journal of Histochemistry: Ejh 41(3): 217-221
Llorente, I.; Goñi, M.J.; Forga, L.; Monreal, M.; Lizcano, F.; Moncada, E. 1992: Clinical usefulness of the glucagon test in the study of pancreatic islet cell function Revista de Medicina de la Universidad de Navarra 37(1): 25-29
Muszyński, J. 1979: Methods of laboratory and function tests in the diagnosis of insulin-secreting islet cell tumor Polski Tygodnik Lekarski 34(42): 1645-1647
Holst, J.J.; Schwartz, T.W.; Lovgreen, N.A.; Pedersen, O.; Beck-Nielsen, H. 1983: Diurnal profile of pancreatic polypeptide, pancreatic glucagon, gut glucagon and insulin in human morbid obesity International Journal of Obesity 7(6): 529-538
Claro, A.; Grill, V.; Efendić, S.; Luft, R. 1977: Studies on the mechanisms of somatostatin action on insulin release. IV. effect of somatostatin on cyclic AMP levels and phosphodiesterase activity in isolated rat pancreatic islets Acta Endocrinologica 85(2): 379-388
Arkosy, P.; Sápy, P.; Hauck, M.; Mikó, I.; Furka, I. 1996: Effect of glucagon and somatostatin on pancreatic secretion in dogs Acta Physiologica Hungarica 84(2): 139-146
Bonifacio, E.; Lampasona, V.; Genovese, S.; Ferrari, M.; Bosi, E. 1995: Identification of protein tyrosine phosphatase-like IA2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies Journal of Immunology 155(11): 5419-5426
Klaff, L.J.; Taborsky, G.J. 1987: Role of pancreatic somatostatin in determining glucagon response to arginine and morphine American Journal of Physiology 252(6 Pt 1): E751-E755
Balabolkin, M.I.; Timofeev, A.V.; Danilova, T.I.; Zhuleva, L.I.; Ol'shanskaia, A.A. 1992: The insulin-secreting and proliferative activity of established islet cells in the presence of sulfonylurea Biulleten' Eksperimental'noi Biologii i Meditsiny 114(10): 406-408
Slavnov, V.N.; Epshteĭn, E.V.; Efimov, A.S.; Luchitskiĭ, E.V. 1981: Relation between blood somatostatin concentration and somatotropin, insulin and glucagon secretion in endocrine diseases Problemy Endokrinologii 27(2): 3-6
Bertuzzi, F.; Socci, C.; Berra, C.; Mirenda, V.; Davalli, A.M.; Magistretti, P.; Di Carlo, V.; Pozza, G.; Pontiroli, A.E. 1994: Effects of glucagon and octreotide on pig islet insulin release in response to glucose: an in vitro study Transplantation Proceedings 26(2): 623-624
Efendić, S.; Enzmann, F.; Gutniak, M.; Nylén, A.; Zoltobrocki, M. 1981: Insulin, glucagon and somatostatin in the perfused rat pancreas and the effects of HB 699 (4-(2-(5-chloro-2-metoxy-benzamido)-ethyl)-benzoic acid) Acta Endocrinologica 98(4): 573-579
Goffrini, P.; Peracchia, A. 1977: Personal experience with hypoglycemic islet-cell neoplasms L'Ateneo Parmense. Acta Bio-Medica: Organo Della Societa di Medicina e Scienze Naturali di Parma 48(5): 543-544
Matsuyama, T.; Hoffman, W.H.; Breuer, R.I.; Zuckerman, L.; Lawrence, A.M.; Foa, P.P. 1977: Serum glucose, insulin, total, pancreatic and enteric glucagon in dogs before and after pancreatectomy, in patients with gastrectomy and pyloroplasty and in diabetic children. Effects of insulin and of secretin Materia Medica Polona. Polish Journal of Medicine and Pharmacy 9(2): 124-129
Maruyama, S.; Sugiura, M.; Tomiyama, H.; Aizawa, T.; Ishido, T.; Kinjyo, T.; Kuwae, M.; Mimura, G. 1984: Detection of human circulating islet cell surface antibodies by dispersed rat pancreatic islet cells (III). Examination of clinical significance Rinsho Byori. Japanese Journal of Clinical Pathology 32(3): 291-298
Singh, D.; Yu, S.F. 1974: Insulin secreting pancreatic adenoma demonstrated by selective angiography Singapore Medical Journal 15(1): 69-71
Gorden, P.; Comi, R.J.; Maton, P.N.; Go, V.L. 1989: NIH conference. Somatostatin and somatostatin analogue (SMS 201-995) in treatment of hormone-secreting tumors of the pituitary and gastrointestinal tract and non-neoplastic diseases of the gut Annals of Internal Medicine 110(1): 35-50
Oda, S.; Hagino, A.; Ohneda, A.; Sasaki, Y.; Tsuda, T. 1988: Adrenergic modulation of pancreatic glucagon and insulin secretion in sheep American Journal of Physiology 254(3 Pt 2): R518-R523