Immunosuppression T-lymphocytes in swine, modulated by Cysticercus cellulosae
Molinar, J.L.; Tato, P.; Valles, Y.
Revista Latinoamericana de Microbiologia 29(3): 293-300
1987
ISSN/ISBN: 0187-4640 PMID: 3501874 Document Number: 299747
By using fluoresceinated monoclonal antibodies, it was observed that, in 50% of non-immunized, control hogs that had been infected with 20,000 Taenia solium eggs, the number of helper T lymphocytes from peripheral blood was lower than normal, whereas immunized hogs and the remainder of the controls gave normal value compared to the values obtained from normal hogs. In these T-depleted hogs, the number of implanted cysticerci was not only 2.18 fold greater than in immunized hogs but also 2.4 fold greater than in the remainder of the control hogs. This suggests that a determined number of implanted larvae may be necessary to immunodepress T lymphocytes population, in particular, helper T cells. Moreover, in the most immunodepressed, hog, the B lymphocyets were also diminished. In contrast, in only one hog (16%) of the immunized, infected hogs were the numbers of total T lymphocytes and helper T cells even slighty diminished. A great number (244) of implanted cysticerci was found in the one animal, supporting the concept that the number of cysticerci may influence immune regulation. An intense granulomatous reaction surrounding the cysticerci was observed in immunized hogs. Eosinophils were the predominant cells and were in close contact with the bladder surfaces. Degranulated eosinophils were also observed in larval spiral canals and the granules were seen to adhere intimately to the outer surfaces of larval teguments. Bladder and larval teguments showed obvious signs of degeneration.