Cytohistologic and ultrastructural characteristics of the early stages of the interaction of Candida with epitheliocytes
Bykov, V.L.; Khokhlov, S.E.; Velichko, E.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 104(12): 752-754
1987
ISSN/ISBN: 0365-9615 PMID: 3318956 Document Number: 293858
Cyto-histological and ultrastructural features of the initial stages of the interaction between Candida cells and epitheliocytes of human and animal mucous membranes were studied in vitro and in vivo. The population of epitheliocytes is heterogeneous in its adhesive properties, 15-20% of cells being several times more adhesive than the rest of the population. Within an individual epitheliocyte the adhesion of blastospores was nonuniform, the majority of the latter attaching to the periphery of the cell and to the intercellular boundaries. This was found in cytological smears, histological film preparations and in SEM micrographs, and was also confirmed by the results of morphometric analysis. Ultrastructural analysis has revealed two phases of the interaction between Candida blastospores and epitheliocytes during adhesion, as well as the cytological effect of the fungal cells.