Effect of encainide on in vivo drug metabolism in the rat
Svensson, C.K.; Knowlton, P.W.
Research Communications in Chemical Pathology and Pharmacology 56(2): 285-288
1987
ISSN/ISBN: 0034-5164 PMID: 3110886 Document Number: 286801
The effect of encainide, an investigational antiarrhythmic, on drug metabolism was examined using the model substrate antipyrine. Administration of a single oral dose of encainide hydrochloride 100 mg/kg one hour prior to antipyrine administration resulted in a mean 30% reduction in antipyrine clearance. These data indicate that encainide, like other agents subject to substantial first-pass metabolism, is capable of inhibiting oxidative drug metabolism.