Effect of calorie restriction on in vivo glucose metabolism by individual tissues in rats
Wetter, T.J.; Gazdag, A.C.; Dean, D.J.; Cartee, G.D.
American Journal of Physiology 276(4): E728-E738
1999
ISSN/ISBN: 0002-9513 PMID: 10198310 Document Number: 511513
We evaluated the effects of 8 mo of calorie restriction deoxyglucose clearance for CR was greater than for AL at both times. A small, CR-related decrease in glucose metabolic index (R'g) occurred only at 1500 in the spleen and heart, and this decrease was reversed at 2100. In some tissues (cerebellum, lung, kidney, soleus, and diaphragm), R'g was unaffected by diet, regardless of time. In the other tissues (brown fat, 3 white fat pads, epitrochlearis, plantaris, and gastrocnemius), R'g was higher or tended to be higher for CR vs. AL at one or both times. These findings indicate that 8 mo of CR did not cause a continuous reduction in in vivo glucose uptake by any tissue studied, and, in several insulin-sensitive tissues, glucose uptake was at times greater for CR vs. AL rats. Reprinted by permission of the publisher.