Effect of aspirin and prostaglandins on the carbohydrate metabolism in albino rats : glucose oxidation through different pathways and glycolytic enzymes
Balasubramanian, A.; Ramakrishnan, S.
Indian Journal of Medical Research 71: 416-420
1980
ISSN/ISBN: 0019-5340 PMID: 7390580 Document Number: 157776
The effect of chronic and acute doses of aspirin and prostaglandin cycle and pentose phosphate pathways and some key glycolytic enzymes of liver were studied in male albino rats. Studies were extended to find the combined effect of PGF2.alpha. and PGE2 with an acute dose of aspirin treatment. The metabolism through the EM-TCA pathway was more pronounced as shown by a reduced ratio of 14CO2 from 1-14C and 6-14C glucose. Two hepatic key glycolytic enzymes, hexokinase and pyruvate kinase, were increased due to aspirin treatment. Withdrawal of aspirin corrected the impaired carbohydrate metabolism in liver. PGF2.alpha. reduced the utilization of 1-14C glucose, while PGE2 increased the utilization of both 1-14C and 6-14C glucose when compared to controls, indicating that different members of PG could affect metabolism differently. Administration of the PG and aspirin together showed an increase in the utilization of 6-14C glucose.