Effect of 17 beta-estradiol and ovariectomy on enzymes of carbohydrate metabolism in regenerating mouse liver
Dixit, A.; Baquer, N.Z.; Rao, A.R.
Biochemistry International 24(4): 649-659
1991
ISSN/ISBN: 0158-5231 PMID: 1799366 Document Number: 386977
Effect of exogenous 17 beta-estradiol and ovariectomy was determined on the activities of some enzymes of carbohydrate metabolism in regenerating mouse liver. 17 beta-estradiol increased liver weight and the activities of these enzymes when given after partial hepatectomy whereas ovariectomy, performed 2 weeks prior to hepatectomy, reduced the activities significantly. Estradiol administration to ovariectomized-partially hepatectomized animals restored the activities of glycolytic enzymes but not of G6P-DH and malic enzyme. This indicates that estradiol acts as a stimulator of growth of proliferating liver as it does in target tissue.