Effects of endotoxin-tolerance on in vivo drug metabolism in mice
Abernathy, C.O.; Zimmerman, H.J.; Utili, R.
Research Communications in Chemical Pathology and Pharmacology 29(1): 193-196
1980
ISSN/ISBN: 0034-5164 PMID: 7403675 Document Number: 155561
Acute doses of endotoxin and the induction of endotoxin-tolerance lowered the apparent in vivo rates of hexobarbital and zoxazolamine metabolism in mice. Acute doses of endotoxin increased the duration of narcosis induced by these two compounds to a greater extent than did induction of the endotoxin-tolerant state. In endotoxin-tolerant mice, however, acute endotoxin treatment did not extend hexobarbital sleeping or zoxazolamine paralysis times beyond those noted in endotoxin-tolerant mice given no acute endotoxin.