Drug-induced immune tolerance to sheep erythrocytes in mice of different lines
Pevnitskiĭ, L.A.; Smirnova, N.N.
Biulleten' Eksperimental'noi Biologii i Meditsiny 82(12): 1461-1464
1976
ISSN/ISBN: 0365-9615 PMID: 1023977 Document Number: 97273
Immunological tolerance to sheep erythrocytes was induced in mice of the CBA, C57BL/6, CC57BR, C3H, DBA/2 lines by means of combined administration of a high dose of the antigen and cyclophosphamide. The count of 19S antibody-forming cells was determined in the mouse spleen after the test injection of erythrocytes, by local hemolysis in gel. The extent of the tolerance induced proved to depend on the genotype of the animals; mice of the DBA/2 line were found to be most "sensitive" to its induction. There was revealed no correlation between the level of the immunological reactivity to sheep erythrocytes in the intact mice of different lines and the extent of its suppression in tolerance induction