Selective delivery of high levels of mitomycin C to peritoneal carcinomatosis using a new dosage form
Hagiwara, A.; Takahashi, T.; Lee, R.; Ueda, T.; Takeda, M.; Itoh, T.
Anticancer Research 6(5): 1161-1164
1986
ISSN/ISBN: 0250-7005 PMID: 3099630 Document Number: 285847
Selective delivery of a high level of Mitomycin C (MMC) in intraperitoneal disseminated lesions was studied using a new dosage form of MMC, called MMC-CH. Intracavitary MMC-CH delivered a much higher level of MMC selectively to intraperitoneal tissues, with a much lower level of MMC in the whole body, in comparison with MMC solution. The index [MMC level in the intraperitoneal organs]: [MMC level in blood] was much higher and increased with time in the MMC-CH group, but not in the MMC solution group.