A new peritoneal carcinomatosis model in cyclosporine immunosuppressed rats
Akhter, J.; Yao, P.; Johnson, L.A.; Riordan, S.M.; Morris, D.L.
Anticancer Research 28(1a): 105-108
2008
ISSN/ISBN: 0250-7005 PMID: 18383831 Document Number: 627843
Colorectal cancer (CRC) cells (HT29) were injected into the intraperitoneal (i.p.) cavity of immunosuppressed male Sprague Dawley rats. Immunosuppression was achieved via a daily i.p. injection of cyclosporine 35 mg/kg/day. Three groups of rats (n =6 per group) were injected with 20, 50 or 100 million HT29 cells. All animals developed tumours indicating that this animal model may prove useful for future research in human colorectal carcinomatosis.