Enkephalinase inhibition by thiorphan and subsequent response of ethanol, normorphine and enkephalins on mouse vas deferens
Blum, K.; Wallace, J.E.; DeLallo, L.; Briggs, A.H.
Functional Neurology 1(2): 156-164
1986
ISSN/ISBN: 0393-5264 PMID: 3301556 Document Number: 285237
In this study, a comparison was made between ethanol, normorphine methionine-enkephalin and [D-ala2] enkephalinamide and the ability of thiorphan, an enkephalinase inhibitor, to potentiate their in vitro activity to inhibit the electrically induced contractions of mouse vas deferens. Thiorphan did not significantly alter the response of either ethanol or normorphine on mouse vas deferens, whereas it significantly potentiated the response of methionine enkephalin.
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