Immunological response in the mouse brain: I. Transplantation immunity to mouse lymphoma graft
Keyaki, A.; Handa, H.; Yamashita, J.; Kuribayashi, K.; Masuda, T.
Nihon Geka Hokan. Archiv für Japanische Chirurgie 57(3): 191-201
1988
ISSN/ISBN: 0003-9152 PMID: 3248016 Document Number: 322892
The immune responses in the mouse brain to intracranially and intradermally transplanted mouse lymphomas were compared by means of an appropriate design of a genetic distance between host and tumor. Antilymphoma graft resistance in the brain was clear not only in the allogeneic combinations, but also in those of the semisyngeneic host and challenging tumor. Enhanced resistance against the second intracranial tumor injection was also observed in all combinations of host mice and tumors. Furthermore, after rejection of the tumors whether implanted intradermally or intracranially, the allogeneic cytotoxic responses were induced to the same extent in the spleens using an in vitro cell-mediated cytotoxicity assay. Using athymic nude mice as recipients, the transplantation resistance detected in the brain was suggested to depend on T-cell mediated immunological responses. In conclusion, we propose that the brain is not an "immunological priviliged" site. The resistance to lymphoma graft in the brain is mediated by T-cells and is dependent on immunological responses which are essentially the same as those seen in peripheral sites.